What Can Stem Cell Technology Do With Patients Of Parkinson’s Disease

You might have heard about the alarming situation, which is being prevailed across UK because of the increasing cases of Parkinson’s disease in this part of the world. Right now, the number of patients of this disease is too high in UK. Medical and scientific researchers are working hard to apply stem cell technology on the patients so that they could treat their disease in safe way. It is Oxford Parkinson’s Disease Center, where efforts are being made in the form of advancement in the field of IPS cell technology. They are trying to make their research even better so that they could use this technology safely on Parkinson’s patients. The best part about the advancement in the field of stem cell technology is that this research is being fully supported by public and private sector. Oxford Parkinson’s Disease Center is receiving considerable about of funds and grants, which are being used for the development of skin-cell-to-brain-cell research program.

The work, researches and studies that have been conducted so far, have helped the researchers to know that this disease is caused when dopamine cells are dead in the body. Now, the researchers take skin cells of the patients and then the cells are concerted into induced pluripotent stem cells. These converted cells are later on converted into dopamine neurons, which are helpful and effective for giving the right treatment to the patients. The reason why skin samples are taken instead of doing brain biopsy of Parkinson’s disease patients is that taking samples is easier and safer for the patients. Moreover, this process gives better and accurate results. When the neurons of patients and non patients are taken and compared, then researchers come to know the reasons due to which dopamine neurons die. Now, Wade-Martins and his team are planning something that would support this research like never before. They are planning to use their Monument Discovery Award for the purpose of doing research on IPS cells technology for the coming 5 years.

provide Custom IPS cells – Transposagen’s exclusive technologies piggyback and rat spermatogonial stem cells (SSCs) are utilized to generate custom stem cell technology faster, cheaper and with higher quality than possible by using standard pronuclear injection methods.

Complications of Peyronies disease

Complications of Peyronies disease.

What it could lead to?

First observed in a time as early as 1687, Peyronies disease was first described by a French surgeon Franois de la Peyronie in 1743 and, hence, was named after him.
Peyronies disease is one of the most bothersome penile / sex-related issues in men. Estimates of the prevalence of Peyronies disease range from less than 1 percent to 23 percent. A recent study in Germany found Peyronies disease in 3.2 percent of men between 30 and 80 years of age. Although the disease occurs mostly in middle age, younger and older men can also develop it. Similarly, statistics show that Peyronies disease is more common in white men with Northern European ancestry and is rarely found in African- American men and Asian men.

Complications of Peyronies disease
If left untreated, Peyronies disease can lead to a number of serious psychological and physiological complications in men such as:
Penile curvature / bending: A plaque on the topside of the shaft, which is most common, causes the penis to bend upward. Similarly, a plaque on the underside causes it to bend downward. In some cases, the plaque develops on both top and bottom, leading to indentation and shortening of the penis. At times, pain, bending, and emotional distress prohibit sexual intercourse. If not corrected or prevented early, this could lead to permanent deformity of the penis.
Hardened tissues on other parts of the body: About 30 percent of men with Peyronies disease develop hardened tissue on other parts of the body, such as the hand or foot. A common example is a condition known as Dupuytrens contracture of the hand.
Urethral stricture: Urethral structure refers to the narrowing or obstruction of urethra (a long tube that carries your stored urine from urinary bladder to penis and, hence, expels it out of the body during urination). The most common cause of such stricture in Peyronies disease is the development of curvature or abnormal shape of the penis which causes a permanent twist / curve in the urethra itself.
Erectile dysfunction (impotence): Peyronies disease can easily lead to erectile dysfunction, the inability to achieve or sustain an erection rm or hard enough for intercourse.
Psycho-social complications: Complications of Peyronie’s disease also include inability to have sexual intercourse and embarrassment over the appearance of the penis. This can severely affect ones sex life and sense of ego, leading to overall deterioration of relations between partners and unhappy social life.

All in all, Peyronies disease is a bothersome, serious penis-related disorder that could negatively affect your sexual, physical and social life in multiple ways. Therefore, it is best to seek early solution of the problem as soon as any of the signs or symptoms is discovered.

Degenerative Disc Disease And Treatment

Nearly all parts of your body show signs of wear and tear as you age. Your spine is no different. However, even though the vertebra shows signs and symptoms of age in everybody, not everyone suffers from degenerative disc disease.

The spine consists of the vertebra and intervertebral discs. Degenerative disc disease attacks the discs in the spine. The term Degenerative Disc Disease is misleading because this is not a disease. Rather, it is a condition where age, strain and minor injuries add up to damage the intervertebral discs in the spine. Over the course of time, continuous strain leads to a degeneration of the discs.

What happens in the degenerative disc disease?
Your spine is made up of a number of vertebrae. There are discs in between the vertebra. The function of these discs is to cushion the vertebra, absorb shock and keep the spine flexible somewhat similar to the role of shock absorbers in a car.

When the intervertebral discs begin to get damaged, tiny scar tissues form over the torn or damaged ligaments. These are not as strong as the normal ligaments present in the discs. Further injury tears the scar tissue. Ultimately the pulp inside the disc loses water and it becomes stiff and the disc collapses. When this happens, bone spurs may start growing around the disc spaces. This is the bodys natural defense response as it tries to reduce the friction between the bones of the vertebra. However, these spurs can cause excruciating pain if they grow inwards and start to press against the nerves in the spinal cord. This condition is known as spinal stenosis.

The most common symptom of a degenerative disc is acute back pain. This pain is caused due to two factors: instability of movement and inflammation of the degenerated discs. So, any treatment of the degenerative disc has to target both the instability as well as the inflammation. Generally, doctors advise a combination of treatments since passive treatments have little effect on their own.

Passive treatments of degenerative discs include:
– Medication for the pain
– Chiropractic manipulation
– Massage
– Epidural injections
– Ultrasound treatments (to warm the area to bring pain relief)

In addition to these, doctors also advise acupuncture, cold or hot compress and behavioral therapy. Active treatments of degenerative disc include weight loss, exercises and proper ergonomics (proper lifting techniques, proper furniture and proper posture).

If patients experience chronic pain in spite of these treatment methods, doctors recommend:
– Surgical intervention, or
– Artificial disc replacement

Surgery becomes unavoidable if patients suffer from back pain, leg pain, stiffness and numbness in the back and if there is difficulty in walking. There are a number of surgical treatments, and the doctor decides on the appropriate treatment methods based on the severity of the problem.

Anyone Can Be Affected By Lyme Disease Symptoms

Lyme Disease is tricky to diagnose the symptoms of. Ticks that cause Lyme Disease are not always easy to see some are even as small as the period at the end of this sentence. The symptoms of lyme disease are usually misdiagnosed as something else. The symptoms sometimes do lead to other diseases. In this article we will talk about some of the symptoms. Keep reading if you think you may have some of the symptoms of Lyme Disease.

You may not find out for a while if you have an inflated heart. With all the symptoms taken into account, this symptom is by far one of the hardest to diagnose. Inflammation of the muscles around the heart is not easy for most to discern. Pain the chest, especially around the heart is one indication of this. Difficulty in breathing is another indication of this condition. In addition if you have swelling. Be sure to have your heart checked out by your doctor if you show any of these signs. Any one of these things should lead you to contact your doctor, even if you don’t think you you have Lyme disease. There are some people however who do not show symptoms of Lyme disease until it has progressed into the later stages. These people are bitten and have no side effects or symptoms until the disease progresses. Actually one out of every four people who contract the disease do not show any symptoms. It can discomforting to know this if you happen to reside in an area that has a large problem with Lyme disease. It is important then to do routine checks for ticks if you live in one of these areas.

Another common disorder, that can also be a late stage symptom of Lyme disease is Anxiety and Depression. Progression of Lyme disease often affects the brain and the nervous system. In areas that Lyme disease is common, it is good to know that the later stages of the disease manifest itself through Anxiety and Depression. If you are suffering from anxiety and Depression be sure your doctor checks out your physical body as well as your brain. Many who suffer from Anxiety and Depression find the disorders life changing, however, with the addition of Lyme disease these can be unbearable. Diagnosing Lyme disease can be tricky. This is because Lyme disease symptoms are often mistaken for other symptoms of other diseases. In cases where the person doesn’t show symptoms till later stages of the disease this is even more true. In the end, you know your body best, so if you feel a little off, it is better to talk to your doctor. In the end, you may just get the treatment you need when the doctor finds that tick bite.

Complete Information On Caroli Disease

Caroli disease also is known as communicating cavernous ectasia. Caroli’s disease is a rare inherited disorder of the liver. It is characterized by saccular and cystic dilatation of intra-hepatic biliary ducts. Caroli disease is associated with recurrent bacterial cholangitis and stone formation. It is distinct from other diseases that cause ductal dilatation caused by obstruction. It is not one of the many choledochal cyst derivatives. It may be associated with autosomal-recessive polycystic kidney disease. The likely mechanism involves an in utero event that arrests ductal plate remodeling at the level of the larger intrahepatic bile ducts.

Insufficient resorption of the ductal plates leads to the formation of multiple primitive bile ducts surrounding the central portal vein. These enlarge, dilate, and become ectatic. There are two types of Caroli disease. Simple caroli disease simply entails the bile duct dilatation or ectasia that by definition is part of Caroli disease and second is complex Caroli disease, hepatic fibrosis and portal hypertension are present as well. The complex form or syndrome is associated with the presence of bands of fibrous tissue in the liver (congenital hepatic fibrosis) and high blood pressure in the portal artery (portal hypertension).

Caroli disease predominantly affects females. The treatment for a caroli disease depends on a number of factors including your health and the size and position of the this inherited disorder. Liver transplantation may be required. This is the best alternative when recurrent cholangitis is not present. Antibiotic treatment with broad-spectrum agents is extremely important.Ultrasonography is very helpful. It is the examination of choice. They are largest in the superior part of the liver. The intraluminal portal vein sign is related to the protrusion of the portal vein branches into the cyst wall.

Color flowing Doppler ultrasonography is useful in showing blood flowing in these branches but no flowing is existing in the bile-containing spaces. Portal branches bridge the cyst walls. Ultrasonography can too assist in the diagnosis of complications and in the follow-up of patients with Caroli disease. Ultrasonography-guided needle ambition of bile from the cystlike lesions may be advantageous in the diagnosis of cholangitis and in confirming that the cysts transmit with the biliary tree. Ultrasonography-guided heart biopsy may be performed, if needed, to receive liver samples for histologic evaluation to affirm this circumstance.

Pick Disease Causes Symptoms Information With Treatment

Pick’s Disease is the result of a build-up of protein in the affected areas of the brain. Pick’s disease is rare. It is more common in women than men. Pick disease occurs in a younger age group than dementia of the Alzheimer type. People with Pick’s disease tend to behave inappropriately in different social settings. The accumulation of abnormal brain cells, known as Pick’s bodies, eventually leads to changes in character, socially inappropriate behavior, and poor decision making, progressing to a severe impairment in intellect, memory and speech. The changes in behavior continue to get worse and are often one of the most disturbing symptoms of the disease. Behavior modification may help some people control unacceptable or dangerous behaviors. In some cases, cognitive function may be improved by stopping or changing medications that worsen confusion or that are not essential to the care of the person. This may include medications such as anticholinergics, analgesics , cimetidine, central nervous system depressants, and lidocaine. Medication to control behaviors that can be dangerous to oneself or others. Antidepressants known as selective serotonin reuptake inhibitors (SSRIs) may offer some relief from apathy and depression. Some patients may need hearing-aids, glasses, cataract surgery , or other treatments.

Causes of Pick Disease

Common Causes and Risk factors of Pick Disease

Longstanding high blood pressure.

Head trauma

High levels of homocysteine.

Female gender because women usually live longer than men.

Schizophrenialike thought disorder.

Signs and Symptoms of Pick Disease

Common Sign and Symptoms of Pick Disease

Lack of muscle coordination.

Brain degeneration.

learning problems.

Loss of muscle tone.

Increased sensitivity to touch.

Spasticity.

Feeding.

Swallowing difficulties.

Enlarged liver and spleen.

Treatment of Pick Disease

Common Treatment of Pick Disease

Behavior modification may help some people control unacceptable or dangerous behaviors.

Many different types of medications have been or are being tried in dementia. One group of drugs used in Alzheimer disease, the cholinesterase inhibitors.

Medication to control behaviors that can be dangerous to oneself or others. Antidepressants known as selective serotonin reuptake inhibitors (SSRIs) may offer some relief from apathy and depression.

Some patients may need hearing-aids, glasses, cataract surgery , or other treatments.

Anti-inflammatory drugs are being tried on the premise that inflammation is one cause of the brain damage in Pick disease.

Hormone replacement therapy has been given to some women who have been through menopause and have dementia.

Education and other forms of intellectual challenge may help protect people against the disease.

High sugar content foods may need to be restricted in some patients with carbohydrate craving, which may indicate Klver-Bucy syndrome.

Prevent Disease Is It Really Possible To Prevent Disease Naturally

Is it really possible to prevent disease and illness naturally without the use of drugs and supplements?

I can tell you today that it is absolutely possible! Disease prevention is no longer just a dream, its a reality.

You dont have to wait for disease and chronic illness to strike and then have to rely upon on doctors and drugs to treat your only your symptoms.

You now have the options to prevent some of the most feared health challenges that will prevent you from having the healthful quality of life you desire.

While there are many incurable diseases, there are many more that are curable and more importantly preventable.

What exactly are you preventing? It is proven that chronic inflammation is at the root cause of many conditions and illnesses such as; aging, allergies, Alzheimers, arthritis, asthma, auto immune diseases, cancer, depression, diabetes, heart disease, insomnia, stroke, and ulcers to name a few.

If you want to live a longer, more healthful and productive life than preventing chronic inflammation in your body is the single most important thing you can do to prevent disease and illness.

This is really important to understand because most Western medicine doctors only treat the symptoms of disease and illness; very few actually focus on why you are sick in the first place. I know this first hand as I was diagnosed with an auto immune disease a few years ago. This is a type of chronic inflammation that had been building up in my body for almost 30 years, before it got to a point where I noticed a big change.

My doctor diagnosed me, wrote me a bunch of prescriptions for steroids, and sent me on my way. I decided to do more research as I did not feel comfortable taking steroids. I found that consuming more fruits would help treat my disease, and prevent it from getting worse. Now it was too late for me to prevent the disease from happening, but I can prevent it from doing even more damage.

Healthy living does not start at the doctors office. It is in your hands. Its your personal responsibility to take care of yourself! It is possible to prevent disease and illness before it even starts.

Comparison Between Lyme Disease And Epstein Barr

Many individuals face the danger of worsening infections and also diseases, due to false assumptions. When it comes to Epstein Barr, many mistake it for Lyme ailment due to many similar symptoms shared by the 2. The following factors will let you see the commonalities as well as distinctions of Lyme disease and Epstein Barr to assist you to understand more about the 2 illnesses:

Cause

While Lyme ailment is caused by the bacteria, Borrelia burgdoferi, Epstein Barr is caused by a virus from the herpes virus family. Lyme ailment could be transmitted via a bite of a tick, usually a deer tick that is contaminated with the bacteria. The virus triggering Epstein Barr, however, can be transported from a contaminated person to another through his or her saliva during romantic contact.

Signs and symptoms

The similarity between the two illnesses is they both reveal flu-like signs and symptoms, like fevers, chills, swollen lymph nodes, and headaches. There are, nevertheless, other symptoms for each infection which make them distinctive from each other. Other Epstein Barr symptoms include an unpleasant sore throat, enlarged tonsils, decrease of appetite, bloating, perspiration, and sometimes, severe fatigue. In unusual situations, the central nervous system might be affected, but Epstein Barr has never been dangerous. Other Lyme disease symptoms, however, include an obvious allergy, erythema migrans, visible during its early stage, and joint pains. The illness, if not diagnosed and handled early, could develop to more serious heart and also nerve problems, along with chronic arthritis.

Diagnosis

Both Lyme disease and Epstein Barr could be identified with blood testing and also clinical tests, accompanied by the patient’s symptoms. The Epstein Barr virus might be verified if there is an increased white blood cell count, and also by the percentage of atypical white cells. A positive response to a “mono spot” test also claims the existence of Epstein Barr virus. For Lyme ailment, it may be easier for the doctor to identify if the patient displays the bulls-eye allergy along with other Lyme disease symptoms and if the sufferer mentions a tick bite. Laboratory tests are then performed to confirm the bacteria leading to Lyme disease.

Treatment solution

At this time, there is no vaccine or anti-viral medications available to avoid and heal Epstein Barr virus. At the moment, steroids are used to lessen swelling of the tonsils and throat. The infection typically takes below 4 months. Alternatively, since Lyme disease is due to bacteria, a period of oral antibiotic remedy must cure the disease. For serious Lyme disease, anti-biotics given intravenously may be necessary for a better treatment.

Lyme diease and Epstein Barr are 2 distinct infections, even with several similar signs and symptoms. You will need to identify one from the other in order avoid false assumptions. To be safe, always visit your physician for a proper diagnosis and treatment.

Risk Factors for Heart Disease-Health

The risk factors for cardiovascular disease have been categorized by the american heart association (AHA) as follows:

Major risk factors that cannot be changed (increasing age, male gender, and heredity)

Major risk factors that can be changed (elevated blood cholesterol levels, high blood pressure, cigarette smoking, and physical inactivity

Other contributing factors (obesity, diabetes, and stress).

Major Risk Factors That Cannot Be Changed

Age

Approximately 55% of all heart attacks occur in people who are 65 years of age or older. This age group accounts for more than 80% of the fatal heart attacks.

Male Gender

Until recently, the incidence of coronary heart disease among women has been largely unexplored. Men have been the primary subjects in the coronary heart disease and risk factor studies because of the high incidence of both among men. However, coronary heart disease is also the leading cause of death and disability among women, accounting for almost 250,000 deaths annually. Women have less heart disease than men, particularly before menopause. The reasons for the difference include the following:

The female hormone estrogen protects the coronary arteries from atherosclerosis

Women have higher circulating levels of high density lipoprotein (HDL) cholesterol, which also protects the arteries.

After menopause, though, the heart attack rate among women increases significantly until the mid-60s, when women’s risk is equal to that of men the same age. An alarming trend in recent years is the increased incidence of heart attacks in premenopausal women who have been smoking cigarettes long enough for it to affect their health, especially when combined with oral contraceptive use.

Heredity

According to the AHA, “A tendency toward heart disease or atherosclerosis appears to be hereditary, so children of parents with cardiovascular disease are more likely to develop it themselves.” A history of first degree male relatives (father, grandfather, and brothers) who died of coronary heart disease before the age of 55 or first degree female relatives (mother, grandmother, and sisters) who died of coronary heart disease before the age of 65 indicates a strong familial tendency. If the family history is positive, the modifiable risk factors must be controlled.

Major Risk Factors That Can Be Changed

Cholesterol

Cholesterol is a steroid that is an essential structural component of neural tissue; it is used in the construction of cell walls and for the manufacture of hormones and bile (for the digestion and absorption of fats). A certain amount of cholesterol is required for good health, but high levels in the blood are associated with heart attacks and strokes.

The AHA suggests that Americans reduce cholesterol consumption to less than 300 milligrams per day (300 mg/day), that fat intake be reduced to a maximum of 30% of the total calories consumed, and that saturated fat be reduced to no more than 10% of the total calories. Many authorities are convinced that limiting total fat and saturated fat is more important than being overly restrictive of cholesterol.